St. Michael’s scientist is leading global research on COVID-19
Dr. Mario Ostrowski will use antibodies from recovered patients to neutralize the virus.
There’s still a lot we don’t know about the COVID-19 virus wreaking havoc on the world right now, but our scientists are working relentlessly on ways to understand and defeat it. Dr. Mario Ostrowski, an infectious disease physician at St. Michael’s Hospital, normally specializes in studying immune responses to HIV and Hepatitis C. But now, in the midst of the COVID-19 pandemic, he is leading an international effort to develop therapies using antibodies from patients who have recovered from the disease.
Dr. Ostrowski and his team are collecting blood cells for the study using a procedure called leukapheresis, in which a patient is hooked up to a machine that gathers a massive number of cells and then returns their blood to them. “In order to really intensively study the immune response against a pathogen like COVID-19, you need large numbers of immune cells, much more than you can get in a regular blood draw,” he explains. “So leukapheresis is a very valuable resource.”
While a regular blood sample might allow researchers to do one or two experiments, one two-hour leukapheresis procedure provides billions of immune cells, meaning one person can contribute to multiple COVID-19 research projects around the world. And that is enabling some exciting collaborations and even leading to breakthroughs. Dr. Ostrowski sent one patient’s sample to a U.S. investigator, James Crowe, at Vanderbilt Medical Center, who was able to identify cells making antibodies that can neutralize the virus. “In a couple of months he’ll be able to synthesize that antibody in large amounts and create a therapeutic that could stop the virus from replicating in sick patients,” he says.
Another collaboration involves immunologists teaming up with structural biologists to determine exactly where on the virus the antibodies are binding. “If we can do that,” says Dr. Ostrowski, “vaccine companies can use that region of the virus rather than other parts that might not work. This study will help the vaccine community make a proper vaccine.”
Dr. Ostrowski cautions that it will take time to produce an effective vaccine for COVID-19. “There are a number of vaccine trials going on right now,” he says. “We’re working with a vaccine company here in Toronto that should be ready to start clinical trials in September. The most important thing is safety, of course, because vaccines are given widely, and we need to make sure the vaccines won’t cause side effects or make the disease worse. It’s especially important with this virus, because we still don’t know too much about it.” That includes how quickly it’s mutating, how long recovered patients might be immune, and whether the antibodies will work on other strains of the virus.
Still, Dr. Ostrowski is optimistic. “It’s really exciting to see how fast the world is responding to this pathogen,” he says. “Everyone wants to solve this problem together.”
Our renowned scientists are at the forefront of the global race to end COVID-19. Support life-saving science by donating to St. Michael’s Power Fund.
St. Michael’s NICU volunteer cuddlers care for fragile babies when their own families can’t
Hospitals all over Canada are reaching out to St. Michael’s for advice on how to set up their own cuddling programs.Read article
Learning from the First Wave to Manage the Second
Dr. Matthew Muller, Medical Director of Infection Prevention and Control at St. Michael’s, shares his views on staying safe through the winter and an update on the hospital’s response.Read article
How Beulah Jarvis got her life back
Research has shown that free essential medication saves lives and billions of dollars for the health system.Read article
Esports with a heart and a cause
Toronto Alpha Flight defeats all opponents in esport “fight for your city” and raises money for St. Michael’s trauma and neuro ICU.Read article
Cycling docs climb mountains to support trauma patients
St. Michael’s physicians biked through the Alps to raise funds for the hospital’s MyBeST Trauma Survivors’ Network, the first of its kind in Canada.Read article
Why new parents of twins are giving back to St. Michael’s NICU
Danielle and Chris were so pleased with St. Michael’s that they became monthly donors. “And if we ever win the lottery,” Danielle adds, “I’m going to donate a lot of money and name the NICU after our kids.”Read article